组学汇总数据深度解读工具

      基因组关系的探索工具XGR涵盖“富集分析”、“相似分析”、“网络分析”与“注解分析”这四大基本分析方法。该工作发表在Genome Medicine (2016),收录于F1000并获高度评价“Exceptional: a major new tool in this field”,迄今下载量为2万7千多次(数据由CRAN提供),受邀撰写由Springer出版Methods in Molecular Biology经典丛书系列专著《Epistasis:Methods and Protocols》第22章节。应用于急性早幼粒细胞白血病PML/RARa异常转录调控组深度解析,成果发表在Blood (2021),同期刊专家高度点评《PML/RARa: changing myeloid networks》——重新定义致病蛋白的双重调控新理论。应用于新型冠状病毒肺炎的宿主多组学图谱解析,合作成果发表在Cell Research(2021)、Cell Discovery(2021)、以及Cell(2022)。



    OpenXGR: a web-server update for genomic summary data interpretation

    Nucleic Acids Research 2023

    DOI: 10.1093/nar/gkad357

    A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

    Cell 2022

    DOI: 10.1016/j.cell.2022.01.012

    A PML/RARα direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia

    Blood 2021

    DOI: 10.1182/blood.2020005698

    Identification of copy number variation-driven molecular subtypes informative for prognosis and treatment in pancreatic adenocarcinoma of a Chinese cohort

    EBioMedicine 2021

    DOI: 10.1016/j.ebiom.2021.103716

    Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19

    Cell Discovery 2021

    DOI: 10.1038/s41421-021-00274-1

    Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2pos subjects

    Cell Research 2021

    DOI: 10.1038/s41422-021-00562-1

    Genetic Interaction Network Interpretation: A Tidy Data Science Perspective

    Epistasis: Methods and Protocols 2021

    DOI: 10.1007/978-1-0716-0947-7_22

    XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits
    Access the recommendation on F1000Prime

    Genome Medicine 2016

    DOI: 10.1186/s13073-016-0384-y

    The 'dnet' approach promotes emerging research on cancer patient survival

    Genome Medicine 2014

    DOI: 10.1186/s13073-014-0064-8